Pick Disease - StatPearls - NCBI Bookshelf
Frontotemporal dementia (FTD) is a progressive, neurodegenerative disorder characterized by behavioral changes and language deficits with frontal and temporal cortical degeneration. It is a heterogeneous condition featuring a variegated constellation of overlapping clinical, genetic, and pathological variables resulting in an individual phenotypic expression of disease. Often referred to as Pick's disease, this dementia syndrome commonly occurs in pre-senile patients and is divided into behavioral variant (bvFTD) and primary progressive aphasia (PPA) subtypes. PPA is further categorized as nonfluent/agrammatic variant (nfvPPA), semantic variant (svPPA), and logopenic aphasia. Motor neuron disease (FTD-MND), progressive supranuclear palsy (PSP-S), and corticobasal syndrome (CBS) are overlapping syndromes falling within the spectrum of the frontotemporal diagnosis.[1]
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