Clinical presentation, diagnosis, and staging of colorectal cancer - UpToDate

INTRODUCTION Colorectal cancer (CRC) is a common and lethal disease. It is estimated that approximately 151,030 new cases of large bowel cancer are diagnosed annually in the United States [1], of which approximately 106,180 arise from colon and the remainder from the rectum. Approximately 52,580 Americans are expected to die of large bowel cancer each year. Although CRC mortality has been progressively declining since 1990, at a current rate of approximately 1.2 percent per year [2], it still remains the third most common cause of cancer death in the United States in women and the second leading cause of death in men. Global, country-specific incidence and mortality rates are available from the World Health Organization (WHO) GLOBOCAN database. In contrast to these declines, the incidence of CRC in men and women under the age of 50 steadily increased at a rate of 2.1 percent per year from 1992 through 2012 and has continued to increase since then; through 2015 there was a 30 percent in

INTRODUCTION Colorectal cancer (CRC) is a common and lethal disease. It is estimated that approximately 151,030 new cases of large bowel cancer are diagnosed annually in the United States [1], of which approximately 106,180 arise from colon and the remainder from the rectum. Approximately 52,580 Americans are expected to die of large bowel cancer each year. Although CRC mortality has been progressively declining since 1990, at a current rate of approximately 1.2 percent per year [2], it still remains the third most common cause of cancer death in the United States in women and the second leadi