Hoogsteen base pair - Wikipedia
A Hoogsteen base pair is a variation of base-pairing in nucleic acids such as the A•T pair. In this manner, two nucleobases, one on each strand, can be held together by hydrogen bonds in the major groove. A Hoogsteen base pair applies the N7 position of the purine base (as a hydrogen bond acceptor) and C6 amino group (as a donor), which bind the Watson–Crick (N3–C4) face of the pyrimidine base.
Hoogsteen base pair - Wikipedia Jump to content From Wikipedia, the free encyclopedia Nucleic acid pairing variations Chemical structures for Watson–Crick and Hoogsteen A•T and G•C+ base pairs. The Hoogsteen geometry can be achieved by purine rotation around the glycosidic bond (χ) and base-flipping (θ), affecting simultaneously C8 and C1 ′ (yellow). [ 1 ] A Hoogsteen base pair is a variation of base-pairing in nucleic acids such as the A•T pair. In this manner, two nucleobases , one on each strand, can be held together by hydrogen bonds in the major groove. Specifically, it happens when a pyr
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