Gastric cancer screening - UpToDate

Screening and surveillance of individuals at increased risk for gastric cancer in the United States (June 2025) Universal screening programs for gastric cancer (GC) exist in several countries with a high incidence of gastric cancer. Although the incidence of gastric cancer in the United States is low, some population subgroups are at elevated risk of gastric cancer but do not routinely receive GC screening. In its recent clinical practice update, the American Gastroenterological Association (AGA) recommends GC screening and surveillance with upper endoscopy in these individuals [1]. This includes those who are first-generation immigrants from regions with a high incidence of GC or have a family history of GC in a first-degree relative without a known hereditary cancer syndrome. We also suggest screening in these patients, but because the effect on cancer-related mortality is uncertain, we individualize screening decisions after discussing the potential benefits and harms with each pati

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