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Research | Mugler Group | University of Pittsburgh

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Cells perform computations using networks of interacting molecules. It is tempting to think of these networks like electronic circuits, but in reality their components are under vastly different physical constraints. Molecules in cells are produced and destroyed at random times, are subject to large fluctuations in their numbers, and must execute random walks through crowded environments in order to interact. How can anything reliable be computed under such conditions? The Mugler Group aims to answer this question using a wide range of theoretical and computational tools, including stochastic modeling, statistical physics, and information theory. We are tackling problems that range from the molecular to the multicellular level, often in collaboration with experimental groups, with the goal to create a better understanding of biological systems and help combat diseases such as cancer. Cells from bacteria to amoebae to human tissue use cell-to-cell communication to coordinate behavior. O

Research | Mugler Group | University of Pittsburgh Skip to main content Mugler Group Use this for to search the site. Search Toggle navigation Home Research Publications Talks Code Teaching Outreach Members Openings Contact CV Research Life is noisy and multi-scale: noisy molecular reactions drive cell sensing and division. Noisy division events drive population growth and structure. One might think that noise at small scales gets averaged out at large scales, but surprisingly, this is not the case. How do cells perform reliable functions in the face of this noise? The Mugler group addresses t

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