Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex | Development | The Company of Biologists

Sarah V. Paramore, Katharine Goodwin, Eric W. Fowler, Danelle Devenport, Celeste M. Nelson; Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex. Development 15 August 2024; 151 (16): dev202692. doi: https://doi.org/10.1242/dev.202692 Download citation file: Adult mammalian lungs exhibit a fractal pattern, as each successive generation of airways is a fraction of the size of the parental branch. Achieving this structure likely requires precise control of airway length and diameter, as the embryonic airways initially lack the fractal scaling observed in the adult. In monolayers and tubes, directional growth can be regulated by the planar cell polarity (PCP) complex. Here, we characterized the roles of PCP complex components in airway initiation, elongation and widening during branching morphogenesis of the lung. Using tissue-specific knockout mice, we surprisingly found that branching morphogenesis proceeds independent

Sarah V. Paramore, Katharine Goodwin, Eric W. Fowler, Danelle Devenport, Celeste M. Nelson; Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex. Development 15 August 2024; 151 (16): dev202692. doi: https://doi.org/10.1242/dev.202692 Download citation file: Adult mammalian lungs exhibit a fractal pattern, as each successive generation of airways is a fraction of the size of the parental branch. Achieving this structure likely requires precise control of airway length and diameter, as the embryonic airways initially lack the