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What is the Renin-Angiotensin-Aldosterone System?

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The renin-angiotensin-aldosterone system (RAAS), or renin-angiotensin-system (RAS) is a regulator of blood pressure and cardiovascular function. Dysregulated RAAS is implicated in high blood pressure, cardiovascular and kidney conditions, and medications targeting RAAS can improve these conditions. Dysfunction of the RAAS is also thought to be implicated in COVID-19 severity and targeting RAAS may be a potential therapeutic strategy for COVID-19 complications. Image Credit: kurhan/Shutterstock.com The RAAS is a complex multi-organ endocrine (hormone) system involved in the regulation of blood pressure by balancing fluid and electrolyte levels, as well as regulating vascular resistance & tone. RAAS regulates sodium and water absorption in the kidney thus directly having an impact on systemic blood pressure. Typically, RAAS is activated when there is a drop in blood pressure (reduced blood volume) to increase water and electrolyte reabsorption in the kidney; which compensates for the dro

What is the Renin-Angiotensin-Aldosterone System? What is the Renin-Angiotensin-Aldosterone System? Download PDF Copy Add News Medical on Google as a preferred source By Dr. Osman Shabir, PhD Reviewed by Sophia Coveney The renin-angiotensin-aldosterone system (RAAS), or renin-angiotensin-system (RAS) is a regulator of blood pressure and cardiovascular function. Dysregulated RAAS is implicated in high blood pressure, cardiovascular and kidney conditions, and medications targeting RAAS can improve these conditions. Dysfunction of the RAAS is also thought to be implicated in COVID-19 severity and

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