Tau protein
The tau proteins (abbreviated from tubulin associated unit) are a group of six highly soluble protein isoforms produced by alternative splicing from the gene MAPT (microtubule-associated protein tau). They have roles primarily in maintaining the stability of microtubules in axons and are abundant in the neurons of the central nervous system (CNS), where the cerebral cortex has the highest abundance. They are less common elsewhere but are also expressed at very low levels in CNS astrocytes and oligodendrocytes.Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become hyperphosphorylated insoluble aggregates called neurofibrillary tangles. The tau proteins were identified in 1975 as heat-stable proteins essential for microtubule assembly, and since then they have been characterized as intrinsically disordered proteins.
Tau protein - Wikipedia Jump to content From Wikipedia, the free encyclopedia Group of six protein isoforms produced from the MAPT gene MAPT Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I8H , 4GLR , 2ON9 , 3OVL , 4E0M , 4E0N , 4E0O , 4FL5 , 4NP8 , 2MZ7 , 4TQE , 4Y5I , 4Y32 , 5DMG , 4Y3B , 5HF3 , 5E2W , 5E2V Identifiers Aliases MAPT , DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule associated protein tau, Tau proteins, tau-40 External IDs OMIM : 157140 ; MGI : 97180 ; HomoloGene : 74962 ; GeneCards : MAPT ; OMA : MAPT - orthologs Gene loc
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