High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch | Communications Biology

In order to investigate the information encoded by spiking activity in different neuronal cell types in the primary somatosensory cortex, de Kock et al performed electrophysiological recordings in untrained rats. They demonstrated that an increase in high-frequency burst spiking in thick tufted pyramids in layer 5 of the cortex allow accurate encoding of exploratory whisker touch.

Download PDF Subjects Sensory processing Whisker system Abstract Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. We find major differences across layers and cell-types. The temporal structure of spontaneous spikin

related reading

• Physiology of Layer 5 Pyramidal Neurons in Mouse Primary Visual Cortex: Coincidence Detection through Bursting | PLOS Computational Biologyjournals.plos.org
• The geometry of cortical representations of touch in rodents | bioRxivbiorxiv.org
• The Unbearable Slowness of Beingarxiv.org
• POYO-1poyo-brain.github.io
• A burst-dependent thalamocortical substrate for perceptual awareness | PLOS Computational Biologyjournals.plos.org
• Sub-threshold neuronal activity and the dynamical regime of cerebral cortex | Nature Communicationsnature.com
• Order matters: neurons in the human brain fire in sequences that encode informationnature.com
• Touch: The Skin – Foundations of Neuroscienceopenbooks.lib.msu.edu
• The Stimulus Selectivity and Connectivity of Layer Six Principal Cells Reveals Cortical Microcircuits Underlying Visual Processing - PMCncbi.nlm.nih.gov
• UC Berkeley Library Proxy Loginwww-nature-com.libproxy.berkeley.edu
• Thinking on the Go: Why Does the Whole Brain Light Up for Just the Smallest Movements?simonsfoundation.org
• Gabriele Sarti on X: "Today in neuro: RoPE for brains? [R]otating waves, which propagate along a circular trajectory, were a prominent and frequently occurring feature [...] [T]hey may serve as a mechanism for coordinating information flow x.com