The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis | Journal of Cell Biology | Rockefeller University Press

Luka Sheppard’s current affiliation is Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Luka Sheppard, David G. Green, Gerald Lerchbaumer, Katheryn E. Rothenberg, Rodrigo Fernandez-Gonzalez, Ulrich Tepass; The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis. J Cell Biol 6 February 2023; 222 (2): e202108091. doi: https://doi.org/10.1083/jcb.202108091 Download citation file: α-Catenin couples the cadherin–catenin complex to the actin cytoskeleton. The mechanosensitive α-Catenin M region undergoes conformational changes upon application of force to recruit interaction partners. Here, we took advantage of the tension landscape in the Drosophila embryo to define three different states of α-Catenin mechanosensing in support of cell adhesion. Low-, medium-, and high-tension contacts showed a corresponding recruitment of Vinculin and Ajuba, which was dependent on the α-Catenin M region. In contrast, the Afadin homolog Canoe a

Luka Sheppard’s current affiliation is Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Luka Sheppard, David G. Green, Gerald Lerchbaumer, Katheryn E. Rothenberg, Rodrigo Fernandez-Gonzalez, Ulrich Tepass; The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis. J Cell Biol 6 February 2023; 222 (2): e202108091. doi: https://doi.org/10.1083/jcb.202108091 Download citation file: α-Catenin couples the cadherin–catenin complex to the actin cytoskeleton. The mechanosensitive α-Catenin M region undergoes conformational changes upon app