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Clinically relevant phenotypes in chronic rhinosinusitis | Journal of Otolaryngology - Head & Neck Surgery | Full Text

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Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of CRS with and without nasal polyposis fails to adequately classify patients based upon their etiology of illness. Our aim with this review is discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary CRS: central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. Methods A narrative review of a tertiary rhinology center’s research themes and how they are applied to clinical protocols and practice was assessed. Discussion Diagnosis and treatment of upper and lower airway conditions become increasingly important as phenotypes and endotypes are being described. There are well-described therapies to treat the different phenotypes of CRS, based upon the presumed underlying cause of the inflammatory process. Research continues to shed more light on different endotypes and phenotypes of airway inflammation, however, clinical differentiation of CRS can be applied in clinic practice with three simple phenotypes of CRS. Understanding these different phenotypes and their etiologies allows for further management beyond the ‘maximum medical therapy and then surgery’ approach that has often been used in the management of CRS.

Clinically relevant phenotypes in chronic rhinosinusitis Review Open access Published: 29 May 2019 Volume 48 , article number 23 ( 2019 ) Cite this article You have full access to this open access article Download PDF Save article View saved research Journal of Otolaryngology - Head & Neck Surgery Clinically relevant phenotypes in chronic rhinosinusitis Download PDF Abstract Background Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of

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