Occupation, hobbies, and acute leukemia in adults - ScienceDirect

Among these are genetic factors, environmental factors and lifestyle, drugs, and antecedent blood disorders; of note, there is a significant association between tobacco smoking and AML. Several studies also reported an increased risk of AML 5–7 years after radiation exposure, 4–8 years after exposure to alkylating agents (commonly associated with chromosome 5 and/or 7 abnormalities), and 1–3 years after topoisomerase II inhibitors (specifically, the French-American-British Cooperative Group [FAB] M4 and M5 subtypes, which are typically is associated with MLL gene rearrangements) (Parikh et al., 2011; Khalade et al., 2010; Pogoda and Preston-Martin, 2006; Terry et al., 2005; Preston et al., 1994; Yeasmin et al., 2016; Duker, 2002; Super et al., 1993; Pedersen-Bjergaard and Rowley, 1994; Rauscher, 2004). Previous reports have also suggested a higher risk of APL in electrical workers and in people from industrialized areas, as well as an association with obesity (Pulsoni et al., 1998; Est

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