The development and benefits of metformin in various diseases | SpringerLink
Slider with three content items shown per slide. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Jessica L. Harding, Meda E. Pavkov, … Edward W. Gregg Diana Glovaci, Wenjun Fan & Nathan D. Wong Lin Yi, Andrea B. Maier, … Vidyadhar Kumbhar Elizabeth Sanchez-Rangel & Silvio E. Inzucchi Graham Rena, D. Grahame Hardie & Ewan R. Pearson Zhe Li, Zhenkun Zhang, … Fangxia Guan Aditi Jain, Abhay Vispute, … Mukesh Jaiswal Ji-Kai Liu Frontiers of Medicine volume 17, pages 388–431 (2023)Cite this article 160 Accesses 2 Altmetric Metrics details Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduc
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