Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates: Developmental Cell

Wnt/β-Catenin signaling controls tissue homeostasis and cell fate decisions. The multiprotein destruction complex suppresses signaling in absence of Wnt ligand and is downregulated for pathway activation. Schaefer and Peifer discuss new insights into destruction complex activity and regulation, highlighting evidence that it acts as a biomolecular condensate in pathway control.