Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects | Genetics | Oxford Academic

Jeannine R LaRocque, Diana L Dougherty, Sumreen K Hussain, Jeff Sekelsky, Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects, Genetics, Volume 176, Issue 3, 1 July 2007, Pages 1441–1451, https://doi.org/10.1534/genetics.107.073635 Jeannine R LaRocque, Diana L Dougherty, Sumreen K Hussain, Jeff Sekelsky, Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects, Genetics, Volume 176, Issue 3, 1 July 2007, Pages 1441–1451, https://doi.org/10.1534/genetics.107.073635 The ability to respond to DNA damage and incomplete replication ensures proper duplication and stability of the genome. Two checkpoint kinases, ATM and ATR, are required for DNA damage and replication checkpoint responses. In Drosophila, the ATR ortholog (MEI-41) is essential for preventing entry into mitosis in the presence of DNA damage. In the absence of MEI-41, heterozygosity for the E(mus304) m

Jeannine R LaRocque, Diana L Dougherty, Sumreen K Hussain, Jeff Sekelsky, Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects, Genetics, Volume 176, Issue 3, 1 July 2007, Pages 1441–1451, https://doi.org/10.1534/genetics.107.073635 Jeannine R LaRocque, Diana L Dougherty, Sumreen K Hussain, Jeff Sekelsky, Reducing DNA Polymerase α in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects, Genetics, Volume 176, Issue 3, 1 July 2007, Pages 1441–1451, https://doi.org/10.1534/genetics.107.073635 The