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Development of a targeted BioPROTAC degrader selective for misfolded SOD1 | Nature Communications
nature.com · 37 words · saved by 1 readers
Conventional PROTACs have limited capacity for misfolded proteins. Here, authors develop a BioPROTAC containing an scFv specifically targeting misfolded SOD1, fused to an E3 ligase, and demonstrate a strategy for reducing misfolded SOD1 accumulation.
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