Engineered highs: Reward variability and frequency as potential prerequisites of behavioural addiction - ScienceDirect

Unpredictable delivery of liquid reward also increases dopamine neuron activation in monkey midbrain [15]. Finally, reward uncertainty is also a crucial component of gambling and games of chance, and its role in rewarded behaviours highlights the cross-over between gambling and drug addiction [16–20]. In the context of drug addiction specifically, many studies now use intermittent access (IntA) self-administration procedures to model human patterns of drug seeking and taking [21–24]. Cookies are used by this site. Cookie settings All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, su

Unpredictable delivery of liquid reward also increases dopamine neuron activation in monkey midbrain [15]. Finally, reward uncertainty is also a crucial component of gambling and games of chance, and its role in rewarded behaviours highlights the cross-over between gambling and drug addiction [16–20]. In the context of drug addiction specifically, many studies now use intermittent access (IntA) self-administration procedures to model human patterns of drug seeking and taking [21–24]. Cookies are used by this site. Cookie settings All content on this site: Copyright © 2025 Elsevier B.V., its li