Drops and fibers — how biomolecular condensates and cytoskeletal filaments influence each other | Emerging Topics in Life Sciences | Portland Press

Arginine-rich dipeptide repeat proteins (R-DPRs) disrupt various phase-separated compartments in neurodegenerative disease. In this special Phase Transitions issue of Emerging Topics in Life Sciences, Odeh and Shorter discuss the therapeutic strategies utilised to combat the deleterious effects of R-DPRs. These include the use of small molecule inhibitors, antisense oligonucleotides (ASOs), antibody immunotherapy (anti-DPRs), and “bait” RNAs. Find out more on pages 293–305. Tina Wiegand, Anthony A. Hyman; Drops and fibers — how biomolecular condensates and cytoskeletal filaments influence each other. Emerg Top Life Sci 11 December 2020; 4 (3): 247–261. doi: https://doi.org/10.1042/ETLS20190174 Download citation file: The cellular cytoskeleton self-organizes by specific monomer–monomer interactions resulting in the polymerization of filaments. While we have long thought about the role of polymerization in cytoskeleton formation, we have only begun to consider the role of condensation in

Arginine-rich dipeptide repeat proteins (R-DPRs) disrupt various phase-separated compartments in neurodegenerative disease. In this special Phase Transitions issue of Emerging Topics in Life Sciences, Odeh and Shorter discuss the therapeutic strategies utilised to combat the deleterious effects of R-DPRs. These include the use of small molecule inhibitors, antisense oligonucleotides (ASOs), antibody immunotherapy (anti-DPRs), and “bait” RNAs. Find out more on pages 293–305. Tina Wiegand, Anthony A. Hyman; Drops and fibers — how biomolecular condensates and cytoskeletal filaments influence each