Metaplasticity - an overview | ScienceDirect Topics

Metaplasticity refers to the ability to generate synaptic plasticity (ability of synapses to strengthen or weaken over time in response to their activity level) and can be adaptive or maladaptive. From: Neuroscience & Biobehavioral Reviews, 2015 You might find these chapters and articles relevant to this topic. R.U. Hegemann, ... W.C. Abraham, in Reference Module in Neuroscience and Biobehavioral Psychology , 2017 Metaplasticity refers to an activity-dependent and persistent regulation of subsequently induced synaptic plasticity, such as long-term potentiation (LTP) or long-term depression (LTD). Essentially, metaplasticity entails a change in the physiological or biochemical state of neurons such that the ability to generate synaptic plasticity is altered. A key feature of metaplasticity is that this change, once established, outlasts the triggering (“priming”) bout of activity and persists until a second bout of activity occurs to induce LTP or LTD (Fig. 1). This persistence featur

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