Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior - ScienceDirect

• Two-photon optogenetics in VR enables targeted manipulation of place cell ensembles • Activating specific place cell ensembles drives their spatially associated behavior • Place cell stimulation inhibits endogenous place code expression and triggers remapping • Direct evidence for a causal role of place cells in spatial navigation Two-photon optogenetics in VR enables targeted manipulation of place cell ensembles Activating specific place cell ensembles drives their spatially associated behavior Place cell stimulation inhibits endogenous place code expression and triggers remapping Direct evidence for a causal role of place cells in spatial navigation The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activit

• Two-photon optogenetics in VR enables targeted manipulation of place cell ensembles • Activating specific place cell ensembles drives their spatially associated behavior • Place cell stimulation inhibits endogenous place code expression and triggers remapping • Direct evidence for a causal role of place cells in spatial navigation Two-photon optogenetics in VR enables targeted manipulation of place cell ensembles Activating specific place cell ensembles drives their spatially associated behavior Place cell stimulation inhibits endogenous place code expression and triggers remapping Direct ev