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Cluster Randomized Trials - Rethinking Clinical Trials

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Patrick J. Heagerty, PhD For the NIH Pragmatic Trials Collaboratory Biostatistics and Study Design Core Damon M. Seils, MA Jonathan McCall, MS Cluster randomized trials (CRTs) differ from individually randomized trials in that the unit of randomization is something other than the individual participant or patient. CRTs are in common use in areas such as education and public health research; they are particularly well suited to testing differences in a method or approach to patient care (as opposed to evaluating the physiological effects of an intervention). Watch the video module: Understanding Clustering in Cluster Randomized Trials There are several reasons why a CRT design might be preferred to or more suitable than an individually randomized trial. First, a CRT might be preferred when the target of the intervention is a collective or system rather than a particular person, such as a patient. For example, while an individually randomized trial may be better suited to determining whe

CHAPTER SECTIONS Experimental Designs and Randomization Schemes Section 3 Cluster Randomized Trials Expand Contributors Patrick J. Heagerty, PhD Elizabeth L. Turner, PhD For the NIH Pragmatic Trials Collaboratory Biostatistics and Study Design Core Contributing Editors Damon M. Seils, MA CRTs, also known as group randomized trials, differ from individually randomized trials in that the unit of randomization is something other than the individual participant or patient. CRTs are in common use in areas such as education and public health research; they are particularly well suited to testing dif

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