Sepsis and Septic Shock | Harrison's Principles of Internal Medicine, 21e | AccessMedicine | McGraw Hill Medical

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more. Download the Access App here: iOS and Android Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. Please consult the latest official manual style if you have any questions regarding the format accuracy. Download citation file: Sepsis is a common and deadly disease. More than two millennia ago, Hippocrates wrote that sepsis was characterized by rotting flesh and festering wounds. Several centuries later, Galen described sepsis as a laudable event required for wound healing. Once the germ theory was proposed by Semmelweis, Pasteur, and others in the nineteenth century, sepsis was recast as a systemic infection referred to as “blood poisoning” and was thought to be due to pathogen invasion and spread in the bloodstream of the host. However, germ theory did not fully explain sepsis: many

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