Value of models for membrane budding - ScienceDirect

• Membrane curvature generation is a readout of the underlying biomechanical events. • Computational models help identify the physical principles behind membrane budding. • Tight connection between experiments and models will aid study of design principles. • New experiments should consider how measurements can be related to model parameters. Membrane curvature generation is a readout of the underlying biomechanical events. Computational models help identify the physical principles behind membrane budding. Tight connection between experiments and models will aid study of design principles. New experiments should consider how measurements can be related to model parameters. The budding of membranes and curvature generation is common to many forms of trafficking in cells. Clathrin-mediated endocytosis, as a prototypical example of trafficking, has been studied in great detail using a variety of experimental systems and methods. Recently, advances in experimental methods have led t

• Membrane curvature generation is a readout of the underlying biomechanical events. • Computational models help identify the physical principles behind membrane budding. • Tight connection between experiments and models will aid study of design principles. • New experiments should consider how measurements can be related to model parameters. Membrane curvature generation is a readout of the underlying biomechanical events. Computational models help identify the physical principles behind membrane budding. Tight connection between experiments and models will aid study of design principles. New