Metabolic regulation of the hallmarks of stem cell biology - ScienceDirect

While the Warburg effect is associated with proliferation, the reduction of metabolic features that drive proliferation is associated with quiescence, when cells have entered a state of reversible cell-cycle arrest. These cells display reduced metabolic flux, low mitochondrial activity, and decreased protein production, and manipulation of these processes can result in exit of quiescence.322 Thus, different metabolic states are associated with distinct developmental states, and metabolic switches mark developmental transitions. On the other hand, genetic studies have demonstrated a causal relationship between lower mitochondrial metabolic rates and increased lifespan in several species.44,45,46 These studies suggest important links between species-specific metabolic rates, body growth, and aging, but molecular connections between metabolism and developmental trajectories have started to be unraveled more recently.47,48 In particular, intermediary metabolism has been found to generate m

While the Warburg effect is associated with proliferation, the reduction of metabolic features that drive proliferation is associated with quiescence, when cells have entered a state of reversible cell-cycle arrest. These cells display reduced metabolic flux, low mitochondrial activity, and decreased protein production, and manipulation of these processes can result in exit of quiescence.322 Thus, different metabolic states are associated with distinct developmental states, and metabolic switches mark developmental transitions. On the other hand, genetic studies have demonstrated a causal rela