Metaplastic (chronic) atrophic gastritis - UpToDate

Gastritis usually has an infectious or autoimmune etiology. This topic review discusses the two types of metaplastic (chronic) atrophic gastritis [1,2]. Other forms of gastritis and gastropathy are presented separately. (See "Gastritis: Etiology and diagnosis" and "Acute and chronic gastritis due to Helicobacter pylori" and "Acute hemorrhagic erosive gastropathy and reactive gastropathy" and "Granulomatous gastritis" and "Approach to the patient with large gastric folds".) TERMINOLOGY The term ”metaplastic (chronic) atrophic gastritis” is used to describe a form of chronic gastritis that, in addition to inflammation, is associated with mucosal thinning, loss of specialized cells in gastric glands, and changes in epithelial cell types (ie, metaplasia). Gastric atrophy and metaplasia are preneoplastic conditions, part of a progression of histologic changes leading to gastric adenocarcinoma. Referred to as the Correa cascade, this is a widely accepted model of gastric carcinogenesis in wh

Gastritis usually has an infectious or autoimmune etiology. This topic review discusses the two types of metaplastic (chronic) atrophic gastritis [1,2]. Other forms of gastritis and gastropathy are presented separately. (See "Gastritis: Etiology and diagnosis" and "Acute and chronic gastritis due to Helicobacter pylori" and "Acute hemorrhagic erosive gastropathy and reactive gastropathy" and "Granulomatous gastritis" and "Approach to the patient with large gastric folds".) TERMINOLOGY The term ”metaplastic (chronic) atrophic gastritis” is used to describe a form of chronic gastritis that, in a