After 130 years, the molecular mechanism of action of nitroglycerin is revealed

home PDF Page 1 / 2 fullscreen remove_circle_outline add_circle_outline search group_add more_horiz get_app info list link Commentary After 130 years, the molecular mechanism of action of nitroglycerin is revealed Louis J. Ignarro* Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 N itroglycerin, which was originally syn- thesized by Ascanio Sobrero, was used by Alfred Nobel to manufacture dy- namite. It was in Nobel’s dynamite facto- ries in the late 1860s that the antianginal effect of nitroglycerin was discovered. Two interesting observations were made. First, factory workers on Monday morn- ings often complained of headaches that disappeared over the weekends. Second, factory workers suffering from angina pectoris or heart failure often experienced relief from chest pain during the work week, but which recurred on weekends. Both effects were attributed t

home PDF Page 1 / 2 fullscreen remove_circle_outline add_circle_outline search group_add more_horiz get_app info list link Commentary After 130 years, the molecular mechanism of action of nitroglycerin is revealed Louis J. Ignarro* Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 N itroglycerin, which was originally syn- thesized by Ascanio Sobrero, was used by Alfred Nobel to manufacture dy- namite. It was in Nobel’s dynamite facto- ries in the late 1860s that the antianginal effect of nitroglycerin was discover