A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization - ScienceDirect
Figure 3. Protein-protein interaction network analysis of dependency and marker associations in the Score2 dataset Figure 4. Prioritization of anti-cancer therapeutic targets for different cancer types Figure 5. Cancer-type-specific priority targets Figure 6. Dual markers for gene dependencies and validation analysis Figure 7. Coverage of patients with nominated priority anti-cancer targets Document S1. Figures S1–S7. Table S1. Categorization of the cell lines used in the study, related to Figure 1. Table S2. Gene set enrichment analysis of the pan-cancer non-negative matrix factorization signatures. Table S3. Curated cancer driver genes, putative gene expression markers and transcriptional subtypes for biomarker analysis, related to Figure 1. Table S4. Dependency marker association analysis and classes for selective pan-cancer dependencies, related to Figure 2. Table S5. Target prioritization analysis, including priority scores, biomarkers, tractability, and compound data, related to
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