Prevention of type 2 diabetes mellitus - UpToDate

Type 2 diabetes mellitus is characterized by hyperglycemia, insulin resistance, and impairment in insulin secretion. Although the lifetime risk of type 2 diabetes is high, our ability to predict and prevent type 2 diabetes in the general population is challenging. However, individuals at high risk, including those with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), obesity, close relatives with type 2 diabetes, or who are members of certain ethnic groups (Asian, Hispanic, African American), are appropriate candidates for preventive interventions [1]. Moreover, genetic risk factors for type 2 diabetes have increasingly been identified, and polygenic risk scores may enhance the traditional demographic and clinical risk factor stratification in the future [2]. The prevention of type 2 diabetes mellitus will be reviewed here. The prevalence, risk factors, and screening for type 2 diabetes are discussed elsewhere. (See "Type 2 diabetes mellitus: Prevalence and risk factor

Type 2 diabetes mellitus is characterized by hyperglycemia, insulin resistance, and impairment in insulin secretion. Although the lifetime risk of type 2 diabetes is high, our ability to predict and prevent type 2 diabetes in the general population is challenging. However, individuals at high risk, including those with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), obesity, close relatives with type 2 diabetes, or who are members of certain ethnic groups (Asian, Hispanic, African American), are appropriate candidates for preventive interventions [1]. Moreover, genetic risk f