Management of primary ovarian insufficiency (premature ovarian failure) - UpToDate

This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Select the option that best describes you Contributor Disclosures INTRODUCTION 46,XX primary ovarian insufficiency (POI) is defined as the development of primary hypogonadism before the age of 40 years in women who have a normal karyotype. The presenting symptoms are similar to those of menopause. The age-specific incidence of spontaneous POI is approximately 1 in 250 by age 35 years and 1 in 100 by age 40 years [1]. In its fully developed form, it is associated with oligomenorrhea or amenorrhea, symptoms of estrogen deficiency, and gonadotropin levels in the menopausal range before age 40 years. The terms "premature menopause" and "premature ovarian failure" were used in the past for POI, but both are inaccurate because many patients with spontaneous POI produce estrogen intermittently and ovulate, a few experience intermittent return of regular menses, and, in 5 to 10 percent of

This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Select the option that best describes you Contributor Disclosures INTRODUCTION 46,XX primary ovarian insufficiency (POI) is defined as the development of primary hypogonadism before the age of 40 years in women who have a normal karyotype. The presenting symptoms are similar to those of menopause. The age-specific incidence of spontaneous POI is approximately 1 in 250 by age 35 years and 1 in 100 by age 40 years [1]. In its fully developed form, it is associated with oligomenorrhea or amenorrhea,