Did CRISPR help—or harm—the first-ever gene-edited babies? | Science | AAAS

Since the gene-edited babies known as Lulu and Nana became international news in November 2018, scientific debate and media speculation have swirled around the potential impacts of modifying their gene for CCR5. One recent study prompted the MIT Technology Review to suggest the twins have enhanced memories and learning abilities, leading to copycat stories worldwide that exercised less restraint. And in June, drawing on a population analysis of variants of the gene CCR5 published in Nature Medicine, headlines blared that the girls might have shortened lives. "This interpretation is not valid or responsible," Rasmus Nielsen, a geneticist at the University of California (UC), Berkeley, who led the work, countered in a tweet. A major concern has been that He Jiankui's attempts to cripple CCR5, the gene for a protein on immune cells that HIV uses to infect the cells, also made "off-target" changes elsewhere in the girls' genomes. Those changes could cause cancer or other problems. He conte

Since the gene-edited babies known as Lulu and Nana became international news in November 2018, scientific debate and media speculation have swirled around the potential impacts of modifying their gene for CCR5. One recent study prompted the MIT Technology Review to suggest the twins have enhanced memories and learning abilities, leading to copycat stories worldwide that exercised less restraint. And in June, drawing on a population analysis of variants of the gene CCR5 published in Nature Medicine, headlines blared that the girls might have shortened lives. "This interpretation is not valid o