Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts | Annual Review of Physiology
Vol. 75:621-644 (Volume publication date February 2013) First published online as a Review in Advance on November 26, 2012 https://doi.org/10.1146/annurev-physiol-030212-183712 David Gems1 and Linda Partridge2 1Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom 2Max Planck Institute for Biology of Ageing, Cologne D-50931, Germany; email: Linda.Partridge@age.mpg.de Discovering the biological basis of aging is one of the greatest remaining challenges for science. Work on the biology of aging has discovered a range of interventions and pathways that control aging rate. A picture is emerging of a signaling network that is sensitive to nutritional status and that controls growth, stress resistance, and aging. This network includes the insulin/IGF-1 and target of rapamycin (TOR) pathways and likely mediates the effects of dietary restriction on aging. Yet the biological processes upon which these pathw
Vol. 75:621-644 (Volume publication date February 2013) First published online as a Review in Advance on November 26, 2012 https://doi.org/10.1146/annurev-physiol-030212-183712 David Gems1 and Linda Partridge2 1Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom 2Max Planck Institute for Biology of Ageing, Cologne D-50931, Germany; email: Linda.Partridge@age.mpg.de Discovering the biological basis of aging is one of the greatest remaining challenges for science. Work on the biology of aging has discovered
Explore this link on the map →