Accuracy of clinical diagnosis of Parkinson disease | Neurology

In a metaanalysis of 20 Parkinson disease (PD) studies, Rizzo et al. reported a pooled diagnostic accuracy of 80.6%, ranging from 61.5-95.7%. [1] The most frequent misdiagnoses among clinic-based studies were multiple system atrophy (MSA) (0-9.8%), Lewy body dementia (LBD) (0-7.9%), vascular encephalopathy (VaE) (0-7.7%), and progresssive supranuclear palsy (PSP) (0-6.5%). [1] I reexamined a 50-year retrospective series of 604 patients with clinical diagnoses of PD from 900 autopsy-verified cases of parkinsonism in Austria, [2] using current diagnostic criteria. [3, 4] The diagnosis of idiopathic PD was confirmed neuropathologically in 80.3% of the total (25% associated with Alzheimer disease [AD]), whereas 19.7% had the following diagnoses: LBD (6.3%), MSA (4.0%), subcortical arteriosclerotic encephalopathy (SAE) (3.6%), PSP (3.0%), and others (AD, Pick disease, postencephalitic parkinsonism, vascular parkinsonism) (1.8%). [2] These data from a large clinic-based consecutive autopsy s

In a metaanalysis of 20 Parkinson disease (PD) studies, Rizzo et al. reported a pooled diagnostic accuracy of 80.6%, ranging from 61.5-95.7%. [1] The most frequent misdiagnoses among clinic-based studies were multiple system atrophy (MSA) (0-9.8%), Lewy body dementia (LBD) (0-7.9%), vascular encephalopathy (VaE) (0-7.7%), and progresssive supranuclear palsy (PSP) (0-6.5%). [1] I reexamined a 50-year retrospective series of 604 patients with clinical diagnoses of PD from 900 autopsy-verified cases of parkinsonism in Austria, [2] using current diagnostic criteria. [3, 4] The diagnosis of idiopat