Connecting theory and experiment in cell and tissue mechanics | Journal of Cell Science | The Company of Biologists

Cornelia Schwayer, David B. Brückner; Connecting theory and experiment in cell and tissue mechanics. J Cell Sci 15 December 2023; 136 (24): jcs261515. doi: https://doi.org/10.1242/jcs.261515 Download citation file: Understanding complex living systems, which are fundamentally constrained by physical phenomena, requires combining experimental data with theoretical physical and mathematical models. To develop such models, collaborations between experimental cell biologists and theoreticians are increasingly important but these two groups often face challenges achieving mutual understanding. To help navigate these challenges, this Perspective discusses different modelling approaches, including bottom-up hypothesis-driven and top-down data-driven models, and highlights their strengths and applications. Using cell mechanics as an example, we explore the integration of specific physical models with experimental data from the molecular, cellular and tissue level up to multiscale input. We als

Cornelia Schwayer, David B. Brückner; Connecting theory and experiment in cell and tissue mechanics. J Cell Sci 15 December 2023; 136 (24): jcs261515. doi: https://doi.org/10.1242/jcs.261515 Download citation file: Understanding complex living systems, which are fundamentally constrained by physical phenomena, requires combining experimental data with theoretical physical and mathematical models. To develop such models, collaborations between experimental cell biologists and theoreticians are increasingly important but these two groups often face challenges achieving mutual understanding. To h