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RESEARCH – MITCHELL LAB

mitchell-lab.seas.upenn.edu · 385 words · saved by 1 readers

The biological barriers to drug delivery to target cells and tissues are complex and numerous, and cause drugs to either be degraded or filtered from the body before achieving their desired therapeutic effect. The Mitchell Lab works at the interface of biomaterials science, drug delivery, and cellular and molecular bioengineering to fundamentally understand and overcome biological barriers to drug delivery. The lab applies research findings and the technologies developed to a range of human health applications, including cancer metastasis, immunotherapy, genome editing, cardiovascular disease, and regenerative medicine. Specific research interests include: synthesis of novel biomaterials and nanoparticles for the delivery of nucleic acids (siRNA, miRNA, mRNA, CRISPR-Cas9); investigating the influence of biomaterial chemical structure on in vivo transport to target cells and tissues using high-throughput screening platforms; and novel drug delivery technologies for tissue engineering an

BIOMATERIALS FOR OVERCOMING BIOLOGICAL BARRIERS TO DRUG DELIVERY The biological barriers to drug delivery to target cells and tissues are complex and numerous, and cause drugs to either be degraded or filtered from the body before achieving their desired therapeutic effect. The Mitchell Lab works at the interface of biomaterials science, drug delivery, and cellular and molecular bioengineering to fundamentally understand and overcome biological barriers to drug delivery. The lab applies research findings and the technologies developed to a range of human health applications, including cancer m

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