Clinical manifestations and diagnosis of primary ovarian insufficiency (premature ovarian failure) - UpToDate

This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Select the option that best describes you Contributor Disclosures INTRODUCTION Primary ovarian insufficiency (POI) is defined as the development of hypergonadotropic hypogonadism before the age of 40 years [1]. The presenting symptoms are similar to those of menopause. In its fully developed form, it is associated with oligomenorrhea or amenorrhea, symptoms of estrogen deficiency, and gonadotropin levels in the menopausal range before age 40 years. POI is distinguished from "induced" POI, ie, POI that is due to early bilateral salpingo-oophorectomy (BSO) or gonadotoxic therapies (chemotherapy and radiotherapy). (See "Elective oophorectomy or ovarian conservation at the time of hysterectomy" and "Ovarian failure due to anticancer drugs and radiation".) The clinical manifestations and evaluation of women with POI (focusing on women with a normal karyotype) will be reviewed here. The

This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Select the option that best describes you Contributor Disclosures INTRODUCTION Primary ovarian insufficiency (POI) is defined as the development of hypergonadotropic hypogonadism before the age of 40 years [1]. The presenting symptoms are similar to those of menopause. In its fully developed form, it is associated with oligomenorrhea or amenorrhea, symptoms of estrogen deficiency, and gonadotropin levels in the menopausal range before age 40 years. POI is distinguished from "induced" POI, ie, POI