Role of Serotonin in the Neurobiology of Schizophrenia and Association With Negative Symptoms | Psychiatry and Behavioral Health | JAMA Psychiatry | JAMA Network

Osugo M, Whitehurst T, Erritzoe D, et al. Role of Serotonin in the Neurobiology of Schizophrenia and Association With Negative Symptoms. JAMA Psychiatry. Published online December 10, 2025. doi:10.1001/jamapsychiatry.2025.3430 Question Is serotonin release altered in vivo in schizophrenia, and is it associated with negative symptom severity? Findings In this case-control neuroimaging study that included 54 adults, frontal cortex serotonin release was significantly greater in the 26 people with DSM-5 schizophrenia compared with 28 matched healthy controls. In schizophrenia, greater frontal cortex serotonin release was associated with more severe baseline negative symptoms. Meaning Findings suggest that serotonergic dysfunction in the pathophysiology of schizophrenia was associated with negative symptoms, identifying the regulation of serotonergic neurotransmission as a potential target to treat negative symptoms. Importance The involvement of the serotonin system in the pathophysiol

Osugo M, Whitehurst T, Erritzoe D, et al. Role of Serotonin in the Neurobiology of Schizophrenia and Association With Negative Symptoms. JAMA Psychiatry. Published online December 10, 2025. doi:10.1001/jamapsychiatry.2025.3430 Question Is serotonin release altered in vivo in schizophrenia, and is it associated with negative symptom severity? Findings In this case-control neuroimaging study that included 54 adults, frontal cortex serotonin release was significantly greater in the 26 people with DSM-5 schizophrenia compared with 28 matched healthy controls. In schizophrenia, greater frontal cort