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Is correcting hyperchloremic acidosis beneficial?

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Given that hyperchloremic acidosis is often iatrogenic, and associated with morbidity, it should be avoided whenever possible – Kellum 2006 Filed Under: PULMCrit Δdocument.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Δdocument.getElementById( "ak_js_2" ).setAttribute( "value", ( new Date() ).getTime() ); Hey! Great post as always. Since the hyperchloremic decrease in GFR is mediated by the macula dense sensing chloride via the NaKCC2 transporter, could Lasix be proctevtive in NAGMA induced renal dysfunction? Are you aware if there is an evidence, clinical or otherwise, supporting low dose Lasix (say 10 QID) in this situation? Thanks, Nick I tend to agree with this but bicarbonate in resuscitation fluid is rare for us to use yes, it was beneficial to me. Great post Username Password Remember Me We are the EMCrit Project, a team of independent medical bloggers and podcasters joined together by our common love of cutting-edge care, iconoclastic ramblings

0 Clinical Question 0 An elderly woman presents with renal failure due to severe dehydration from diarrhea. She has a hyperchloremic acidosis from diarrhea with a chloride of 115 mEq/L, bicarbonate of 15 mEq/L, and a normal anion gap. During her volume resuscitation, should isotonic bicarbonate be used to correct her hyperchloremic acidosis? Does correcting her hyperchloremic acidosis actually help her, or does this just make her numbers better? 0 Introduction 0 The use of bicarbonate for treatment of metabolic acidosis is controversial. However, this controversy centers primarily around use o

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