Early Detection of Amyloidopathy in Alzheimer's Mice by Hyperspectral Endoscopy | IOVS | ARVO Journals

Swati S. More, James M. Beach, Robert Vince; Early Detection of Amyloidopathy in Alzheimer's Mice by Hyperspectral Endoscopy. Invest. Ophthalmol. Vis. Sci. 2016;57(7):3231-3238. doi: https://doi.org/10.1167/iovs.15-17406. Download citation file: © ARVO (1962-2015); The Authors (2016-present) Purpose: To describe a spectral imaging system for small animal studies based on noninvasive endoscopy of the retina, and to present time-resolved spectral changes from live Alzheimer's mice prior to cognitive decline, corroborating our previous in vitro findings. Methods: Topical endoscope fundus imaging was modified to use a machine vision camera and tunable wavelength system for acquiring monochromatic images across the visible to near-infrared spectral range. Alzheimer's APP/PS1 mice and age-matched, wild-type mice were imaged monthly from months 3 through 8 to assess changes in the fundus reflection spectrum. Optical changes were fit to Rayleigh light scatter models as measures of amyloid aggr

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