Early detection of cancer | Science

eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter. No eLetters have been published for this article yet. Early detection of lung cancer occurs by observing lung nodules before patients have any symptoms. The authors mention protein biomarkers with a 2012 reference (77). The following year the discovery and validation of a proteomic based blood biomarker was published (Li et al., Sci Transl Med 2013; 5:207ra142). Analytic and clinical validation were completed and approval was received in 2018 (LCD L37216 MolDX: BDX-XL2). As the authors explain, this biomarker has a high senstivity and NPV so

eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter. No eLetters have been published for this article yet. Early detection of lung cancer occurs by observing lung nodules before patients have any symp