All Medications Are Insignificant In The Eyes Of God And Traditional Effect Size Criteria

...

All Medications Are Insignificant In The Eyes Of God And Traditional Effect Size Criteria ... Scott Alexander May 31, 2023 299 200 9 Share SSRI antidepressants like Prozac were first developed in the 1980s and 1990s. The first round of studies, sponsored by pharmaceutical companies, showed they worked great! But skeptics found substantial bias in these early trials; several later analyses that corrected for this all found effect sizes (compared to placebo) of only 0.30. Is an effect size of 0.30 good or bad? The usual answer is “bad”. The UK’s National Institute for Clinical Excellence used to

related reading

• The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it | Alex’s blogatelfo.github.io
• Using Effect Size—or Why the P Value Is Not Enough - PMCncbi.nlm.nih.gov
• What is Effect Size and Why Does It Matter? (Examples)scribbr.com
• Statistical Significance vs. Practical Significance of Research Resultspages.uoregon.edu
• Vitamin D & Omega-3 may have a larger effect on depression than antidepressantsblog.ncase.me
• Antidepressants versus placebo for depression in primary care - PubMedpubmed.ncbi.nlm.nih.gov
• Where are all the trillion dollar biotechs?ladanuzhna.xyz
• The Minimum Effective Dose: Why Less is Morefs.blog
• Effect Size | Research Rundownsresearchrundowns.com
• What Your Therapist Doesn’t Know - The Atlantictheatlantic.com
• Methods for treating depression — LessWronglesswrong.com
• Case Study: The Clinical Translation of Transcranial Magnetic Stimulationmilan.cvitkovic.net