Treatment and prevention of invasive aspergillosis - UpToDate
INTRODUCTION Invasive aspergillosis is the most common mold infection in immunocompromised hosts. This infection is caused by Aspergillus, a hyaline mold that is ubiquitous. Exposure to Aspergillus conidia is frequent, but invasive disease is uncommon because of control by host immunity in nonimmunosuppressed hosts. The most common risk factors for infection include neutropenia and glucocorticoid use, but other risk factors include hematopoietic cell transplantation, solid organ transplantation (particularly lung transplantation), the use of biologic agents, pulmonary diseases, and critical illness. The most common infecting species is Aspergillus fumigatus complex, but other species complexes that are common causes of disease include A. flavus, A. terreus, and A. niger. Less common species, such as A. nidulans, A. calidoustus, A. lentulus, and many others, have been reported to cause infection in highly immunosuppressed patients. Many of these unusual or "cryptic" species, which are o
INTRODUCTION Invasive aspergillosis is the most common mold infection in immunocompromised hosts. This infection is caused by Aspergillus, a hyaline mold that is ubiquitous. Exposure to Aspergillus conidia is frequent, but invasive disease is uncommon because of control by host immunity in nonimmunosuppressed hosts. The most common risk factors for infection include neutropenia and glucocorticoid use, but other risk factors include hematopoietic cell transplantation, solid organ transplantation (particularly lung transplantation), the use of biologic agents, pulmonary diseases, and critical il
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